B. Yang, Sharma, M., and Tunnell, J. W., “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain.,” J Biomed Opt, vol. 18, no. 8, pp. 80503, 2013.
A new approach to retrieve the attenuation-corrected fluorescence using spatial frequency-domain imaging is demonstrated. Both in vitro and ex vivo experiments showed the technique can compensate for the fluorescence attenuation from tissue absorption and scattering. This approach has potential in molecular image-guided surgery.