Bio-Mechano-Optic Stimulation and Sensing (BMOSS)

MOSS is a technology currently under development in the Medical Device Lab. We previously demonstrated the use of mechanical deformation for reducing tissue light scattering and increasing optical penetration depth. Such tissue optical responses are inextricably linked to the mechanical stress/strain state of the tissue, particularly the tissue microstructural response to deformation. BMOSS may be able to take advantage of this coupled relationship to in order to diagnose disease states or study mechanobiological behavior.

Trans-illuminated USAF 1951 resolution target viewed through indented 
ex vivo porcine skin. The intensity profile can be used to evaluate image resolution and contrast.

Dynamic responses of (a) Tissue thickness, (b) Compressive load, and (c) Light transmission in indented 
ex vivo porcine skin samples.