Publications by Type: Miscellaneous

2015
K. P. Johnston, Engstrom, J., and Williams III, R. O., “Formation of stable submicron peptide or protein particles by thin film freezing”. US Patent 8,968,786, 2015. Publisher's VersionAbstract
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
R. O. Williams III, Johnston, K. P., Sinswat, P., McConville, J. T., Talbert, R., Peters, J. I., Watts, A. B., and Rogers, T. L., “Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery”. US Patent App. 14/621,337, 2015. Publisher's VersionAbstract
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
K. P. Johnston, Engstrom, J., and Williams III, R. O., “Formation of stable submicron peptide or protein particles by thin film freezing”. US Patent App. 14/603,211, 2015. Publisher's VersionAbstract
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
C. Huh, Bryant, S. L., Milner, T. E., and Johnston, K. P., “Determination of oil saturation in reservoir rock using paramagnetic nanoparticles and magnetic field”. US Patent 9,133,709, 2015. Publisher's VersionAbstract
Methods for detection of the presence and distribution of oil in subsurface formation are described herein. The present invention involves injection of an aqueous dispersion of the nanoparticles into the potentially oil containing subsurface formation, followed by a remote detection of the oscillation responses of the nanoparticles in the oil/water interfaces in the reservoir rock by applying magnetic field.
C. Huh, Bryant, S. L., Milner, T. E., and Johnston, K. P., “Determination of oil saturation in reservoir rock using paramagnetic nanoparticles and magnetic field”. US Patent App. 14/853,519, 2015. Publisher's VersionAbstract
Methods for detection of the presence and distribution of oil in subsurface formation are described herein. The present invention involves injection of an aqueous dispersion of the nanoparticles into the potentially oil containing subsurface formation, followed by a remote detection of the oscillation responses of the nanoparticles in the oil/water interfaces in the reservoir rock by applying magnetic field.
K. P. Johnston, Truskett, T., Dear, B., Dinin, A., Borwankar, A., and Hung, J., “Low viscosity concentrated protein dispersions”. US Patent App. 14/843,897, 2015. Publisher's VersionAbstract
Disclosed herein are, inter alia, low viscosity dispersions comprising proteins and viscosity lowering agents; pharmaceutical compositions comprising low viscosity dispersions; and methods of making and using the pharmaceutical compositions and low viscosity dispersions.
J. E. Hitt, Rogers, T. L., Gillespie, I. B., Scherzer, B. D., Garcia, P. C., Beck, N. S., Tucker, C. J., Young, T. J., Hayes, D. A., and Williams III, R. O., “Enhanced delivery of drug compositions to treat life threatening infections”. US Patent 9,061,027, 2015. Publisher's VersionAbstract
Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.
R. O. Williams, Johnston, K. P., Sinswat, P., McConville, J. T., Talbert, R., Peters, J. I., Watts, A. B., and Rogers, T. L., “Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery”. US Patent 9,044,391, 2015. Publisher's VersionAbstract
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
A. W. Sanders, Johnston, K. P., Nguyen, Q., Adkins, S., Chen, X., and Rightor, E. G., “Compositions for oil recovery and methods of their use”. US Patent 8,973,668, 2015. Publisher's VersionAbstract
Embodiments of the present disclosure include compositions for use in enhanced oil recovery, and methods of using the compositions for recovering oil. Compositions of the present disclosure include a nonionic, non-emulsifying surfactant having a CO2-philicity in a range of about 1.5 to about 5.0, carbon dioxide in a liquid phase or supercritical phase, and water, where the nonionic, non-emulsifying surfactant promotes a formation of a stable foam formed of carbon dioxide and water
2014
K. P. Johnston, Mazuski, M. A., Engstrom, J., and Rodrigues, M. A., “Low viscosity highly concentrated suspensions”. US Patent 8,779,094, 2014. Publisher's VersionAbstract
The present invention also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
K. P. Johnston, Mazuski, M. A., Engstrom, J., and Rodrigues, M. A., “Low viscosity highly concentrated suspensions”. US Patent App. 14/297,403, 2014. Publisher's VersionAbstract
The present invent ion also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle
A. W. Sanders, Johnston, K. P., Nguyen, Q., Adkins, S., Chen, X., and Rightor, E. G., “Dispersion compositions with nonionic surfactants for use in petroleum recovery”. US Patent 8,695,718, 2014. Publisher's VersionAbstract
Embodiments of the present disclosure include dispersion compositions having a nonionic surfactant for use in enhanced petroleum recovery, and methods of using the dispersion compositions in petroleum recovery processes. For the various embodiments, the nonionic surfactant of the dispersion composition promotes the formation of a dispersion from carbon dioxide and water
2013
B. A. Korgel, Johnston, K. P., Brosh, K., and Thurk, P., “Applications of light-emitting nanoparticles”. Google Patents, 2013.
K. P. Johnston, Bielawski, C. W., Bagaria, H. G., Yoon, K. Y., Neilson, B. M., Huh, C., Bryant, S. L., Foster, E. L., Xue, Z., and Foster, L. M., “Polymer coated nanoparticles”. US Patent App. 14/436,325, 2013. Publisher's VersionAbstract
A magnetic nanoparticle suitable for imaging a geological structure having one or more magnetic metal or metal oxide nanoparticles with a polymer grafted to the surface to form a magnetic nanoparticle, wherein the magnetic nanoparticle displays a colloidal stability under harsh salinity conditions or in a standard API brine.
K. P. Johnston, Williams III, R. O., and Chen, X., “Preparation of drug particles using evaporation precipitation into aqueous solutions”. Google Patents, 2013. Publisher's VersionAbstract
A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug. The present invention additionally contemplates products and processes for new drug formulations of insoluble drug particles having high dissolution rates and extremely high drug-to-excipient ratios