Low viscosity highly concentrated suspensions

Citation:

K. P. Johnston, Mazuski, M. A., Engstrom, J., and Rodrigues, M. A., “Low viscosity highly concentrated suspensions”. US Patent 8,779,094, 2014.

Abstract:

The present invention also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.

Notes:

Publisher's Version