Measurements and modeling of transient blood flow perturbations induced by brief somatosensory stimulation.

Citation:

K. Swanul, Dunn, A. K., Duong, T. Q., and Ress, D., “Measurements and modeling of transient blood flow perturbations induced by brief somatosensory stimulation.,” The open neuroimaging journal, vol. 5, pp. 96–104, 2011.

Abstract:

Proper interpretation of BOLD fMRI and other common functional imaging methods requires an understanding of neurovascular coupling. We used laser speckle-contrast optical imaging to measure blood-flow responses in rat somatosensory cortex elicited by brief (2 s) forepaw stimulation. Results show a large increase in local blood flow speed followed by an undershoot and possible late-time oscillations. The blood flow measurements were modeled using the impulse response of a simple linear network, a four-element windkessel. This model yielded excellent fits to the detailed time courses of activated regions. The four-element windkessel model thus provides a simple explanation and interpretation of the transient blood-flow response, both its initial peak and its late-time behavior.

Notes:

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