Although EOR with CO2 is practiced domestically on large scale, the potential for advancement is enormous. The ongoing search for better solutions has motivated extensive research on alternatives to surfactant-stabilized CO2 foams for CO2 mobility control. The formation of CO2-in-water foams lowers the CO2 mobility, resulting in improvement in sweep efficiency in field tests. The crucial unmet challenge in employing CO2 foams is to maintain long-term stability of foam to achieve high sweep efficiency for the duration of the flooding process. Surfactant-stabilized foams are inherently unstable so that maintenance of the low mobility requires continuous regeneration of lamellae in the small pores of the rock. Nanoparticles can potentially be used to provide much higher foam stability and thus long-term mobility control for CO2 floods. They can act like a foaming surfactant without some of the surfactant drawbacks. Here we present a turnkey approach for using surface treated nanoparticles in reservoirs. This involves: tests for stability in brines, transportability through cores, foam generation in beadpacks and cores when co-injected with CO2, quantification of CO2 viscosity enhancement, and finally modeling of field-scale effects. In this paper, we will outline the key details of nanoparticle design for CO2 EOR.